国内正规彩票app

国内正规彩票app

Chemical synthesis needs to evolve and adapt to the challenges of the future, and free itself from the restraints of laborious and time-consuming processes. New technologies must strive to provide safe, effective and productivity enhancing solutions. Our new automated capsule based synthesiser addresses all these issues and more!

The Synple 2 is the first easy to use automated synthesis device that increases your daliy productivity without any hassles.
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The small and compact capsule-based synthesizer for the generation of research products, works in an analogous manner to a capsule coffee maker. Simply add the starting material to be transformed and a commercially available, single-use, disposable reagent capsule and with a single touch of a button, the product is generated, isolated and purified!
 
Following the generation of the desired product, an automated washing sequence allows the machine to be used directly by another user without risk of contamination. With all the chemicals and solvents required for the transformation, as well as the waste generated, the risk of user exposure is drastically reduced. Thus this technology offers not only time-saving, productivity, and efficiency benefits, but it offers a far safer process than the respective traditional synthetic procedure.
The 3 in 1 solution offers an unprecedented combination of hardware, software and an optimized chemical process. Use of the automated synthesizer, in conjunction with the specialised capsules, offers the opportunity to break free of the limitations imposed by traditional synthesis, and the benefits of a safe, time-efficient, cost effective, plug and play synthetic procedure.

国内正规彩票app

国内正规彩票app

官网棋牌游戏网站送彩金  从行业来看,上周基金配置比例最高的三个行业为食品饮料、家电和医药,配置仓位分别为5.97%、4.78%和4.34%;基金配置比例较低的三个行业为石油石化、国防军工和钢铁,仓位分别为0.46%、0.55%和0.59%”潘秋生表示,在构建直播矩阵的过程中,会涉及到一些试错的过程,比如,从店播的角度来讲,有些店做的很满意,有些店还有继续成长的空间

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国内正规彩票app

  • Reagent cartridges are available for eight distinct reaction classes, with more than different 40 reagents.
  • Each cartridge contains a scannable chip enabling the the standardized reaction sequence to be loaded without any further programming.
  • Key reaction parameters (time, temperature, etc.) can be easily modified.
New reaction application are frequently released to expand the number of reaction types you can run on the same Synple instrument.

Click on the cartridge to see what reagents are contained in them and how the reactions work. A detailed set of application notes is available for each type of cartridge
 
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国内正规彩票app

国内最大的棋牌游戏官网截至2020年9月30日,金山办公主要产品月度活跃用户(MAU)达到4.57亿,较上年同期增长19.63%  作为我国财险业占比超六成的主力险种,车险改革对竞争格局的影响至关重要

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国内正规彩票app

国内正规彩票app

国内正规彩票app

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国内正规彩票app

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国内正规彩票app

Much less working time is required to generate new molecules. The synthesizer will only take 5-10 minutes to set up and will run completely autonomously. This offers the potential to increase the productivity of every synthetic chemist, whatever level of skill and experience.
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国内正规彩票app

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国内正规彩票app

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国内正规彩票app

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国内正规彩票app

With only 25 x 35 cm footprint, the synthesizer uses only a minimum amount of space and fits in every laboratory.
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国内正规彩票app

国民彩票app登录上周末,证监会发布《可转换公司债券管理办法(征求意见稿)》及其说明,向社会公开征求意见

国内正规彩票app

国内正规彩票app

Snyple Chem was founded in 2016 as a Spin-off from ETH Zürich. Our mission is to provide easy to use, safe, efficiency-enhancing solutions that represent the future of organic synthesis. 
 

国内正规彩票app

Now, alongside the Synple 1 and 2, we have our latest addition - the Synple Unity, a flexible parallel synthesiser.
 

国内正规彩票app

No, the cartridges come ready filled with all the reagents and materials required for the reaction, work-up and purification. We can, however, provide custom cartridges for users under certain circumstances.
 

国内正规彩票app

The machine itself is tolerant of almost all solvents. The limitation are only related to what is tolerated in terms of the chemistry by each reaction class. More information can be found in our application notes.
 

国内正规彩票app

In many cases, co-solvents can be added to help solubiulise poorly soluble starting materials. 
 

国内正规彩票app

We provide a scope for each reaction that indicates what is fast reacting and slow reacting. For slower reacting materials we recommend increasing the default reaction time. 

国内正规彩票app

With the Synple 1 and Synple 2, only one reaction can be run at a time. The Synple Unity system allows you to build a parallel synthesis system to suit your own needs.
 

国内正规彩票app

The machine requires very little maintenance and most of the components, e.g. the lines, connections, vial, are all standard. We are also able to offer service and maintenance contracts.
 

国内正规彩票app

Yes! Our Synple 1 machines have been installed with customers since May 2018 and our new Synple 2s have been in use since October 2019.
 

国内正规彩票app

At the moment we sell directly across Europe and the UK. We can also sell direct in the US or alternatively use a distributor. In addition, we are in discussions with several distributors across Asia.
 

国内正规彩票app

The average lead time for the machine is four weeks. Cartridges can be delivered within the week.

国内正规彩票app

This depends on the reaction class and what is tolerated by each particular reaction. In many cases co-solvents can be used to help solubilise the starting material.
 

国内正规彩票app

Each method has been pre-optimised to give the best yield and purity across a broad substrate scope. If optimisation is required then we would recommend skipping the purification step and checking the product at the end of the run. If it has not gone to completion, the reaction can be run again.
 

国内正规彩票app

This is something we are actively exploring.

国内正规彩票app

This is dependant on the reaction class. Each run time includes the reaction, work-up and purification time.
A detailed overview can be found in the ressource section.

国内正规彩票app

We are working with the Synple instrument in our laboratory for several months now
The first reaction tested was the one using SnAP reagents. The interest of this reaction developed by Professor BODE to form original saturated heterocycles was presented to us at a medicinal chemistry symposium a few years ago.
We then purchased the corresponding SnAP reagents sold by Aldrich and tested them under conventional laboratory conditions with original aldehydes and ketones. Although the results were satisfactory, the perspective of using potentially toxic products such as tin derivatives was not very encouraging. This very simple to use synthesizer has not only avoided handling these reagents but also improved the efficiency of the reaction by leading to often clean products with good yields.
Applied to reductive amination reactions, the same technology has led to variable results, more or less satisfactory depending on the type of amines used (salified, primary or secondary).
Two very convincing tests were also carried out on the formation of PROTACs from aldehyde and appropriate pre-filled cartridge.
Ease of use, reproducibility of experiments and non-exposure to toxic chemical substances are the major assets of this new automated synthesizers, which should be developed in particular to support scale-up.

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The machine is really very easy to use. This technology was not really part of our automation strategy but we have been surprised how quickly it was adopted.
 
We have had the Synple instrument in our labs for several months now. We like the instrument and it works perfectly well. We have found that anyone can get good results with the SnAP cartridges without first having to learn the insights of SnAP through painful failures. The same chemistry on the same scale was far better on the instrument than it was in the flask.
The reductive alkylation of secondary amines was successfully achieved using paraformaldehyde and small amine fragments, resulting in water soluble products. The instrument gave the product in good quantity and initial quality. Although the final products did need some further purification, our chemists struggled to reach the same level of quantity and purity when the reaction was performed in a flask.
In summary, the instrument really makes life easier and, especially if there were a way to scale up the reactions in a similarly easy way, then I wouldn’t want anyone in my organization to perform the SnAP and reductive alkylation reactions in the traditional way. Just adding the reagents and then pressing the button is so much easier and reproducible.
The machine is very easy to use and took no more than 10-15 minutes for us to do the whole process. Everyone who has used it thinks that it does increase their productivity. I personally made compounds that I would otherwise not have had the time to make
We consider the instrument very valuable to quickly make a set of PROTACs from scratch.

国内正规彩票app

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